Siberian Ginseng Extract (Eleutherococcus senticosus): An Adaptogenic Powerhouse

Key Bioactive Compounds

• Eleutherosides (0.6-1.2%): Primary marker compounds (B, E particularly bioactive)

• Syringin (Eleutheroside B): Immunomodulatory and neuroprotective effects

• Isofraxidin: AMPK activator with metabolic benefits

• Polysaccharides (up to 35%): Immune-enhancing fractions

Mechanistic Actions

• HPA Axis Modulation: Normalizes cortisol response to stress

• Mitochondrial Optimization: Enhances ATP production efficiency

• Immunoadaptogenic Effects: Increases NK cell activity without overstimulation

• Cognitive Enhancement: Improves cerebral circulation and cholinergic transmission

Clinical Applications

• Adaptogenic Formulations: Stress resilience and fatigue management

• Sports Nutrition: Ergogenic aid for endurance athletes

• Immunonutrition: Post-illness recovery support

• Neuroprotection: Mild cognitive impairment adjunct

Quality Parameters

• Standardization: Minimum 0.8% eleutherosides (HPLC)

• Extract Ratio: 10:1 native extract preferred for full spectrum activity

• Authentication: DNA barcoding to distinguish from adulterants

Therapeutic Dosage

• Maintenance: 100-300 mg/day standardized extract

• Acute Support: Up to 1,000 mg/day (divided doses)

• Duration: Cyclic administration recommended (8-12 weeks)

Safety Profile

• Drug Interactions: May potentiate CNS stimulants

• Contraindications: Autoimmune conditions (theoretical risk)

• Regulatory Status: Approved in EU traditional herbal registrations

This clinically validated adaptogen bridges traditional Siberian medicine with modern performance enhancement applications, offering a balanced approach to stress resilience.