PQQ is called pyrroloquinoline quinone, and is usually used as a single agent (in the form of disodium salt) in the field of health care products. As far as the ingredients are concerned, pyrroloquinoline quinone is a kind of naturally occurring in soil and certain foods. Non-vitamin growth factors. It is also produced in the body and exists in human tissues. It works by promoting the synthesis of new mitochondrial cells, which helps to provide energy for the cells.PQQ disodium salt Powder has been confirmed in human, test tube and animal studies to improve sleep, lower cholesterol levels, reduce oxidative stress, extend life span, promote brain function and relieve inflammation.

Key Characteristics

• Chemical Formula: C₁₄H₄N₂Na₂O₈

• Molecular Weight: 374.17 g/mol

• Appearance: Reddish-brown crystalline powder

• Solubility: Highly water-soluble (>50 mg/mL)

Mechanisms of Action

• Mitochondrial Biogenesis: Stimulates PGC-1α pathway

• Redox Cofactor: Catalyzes electron transfer (5000× more efficient than vitamin C)

• Neuroprotection: Upregulates NGF and BDNF synthesis

• Antioxidant Recycling: Regenerates oxidized vitamin E

Clinical Applications

• Cognitive Support: Enhances memory formation (20 mg/day in trials)

• Cardiometabolic Health: Improves endothelial function

• Exercise Performance: Increases VO₂ max by 12% (athlete studies)

• Anti-Aging: Reduces cellular senescence markers

Technical Specifications

• Purity: ≥98% (HPLC-UV)

• Stability: 24 months at -20°C (desiccated)

• Compatibility: Stable in pH 6-8 formulations

Dosage & Safety

• Effective Range: 10-40 mg/day

• NOAEL: 100 mg/kg/day (rodent)

• Regulatory Status:

• GRAS Notice No. GRN 000333 (FDA)

• Novel Food EU authorization pending

Formulation Notes

• Synergistic Combinations:

• CoQ10 (mitochondrial synergy)

• R-Lipoic Acid (redox cycling)

• Delivery Systems:

• Sublingual tablets for enhanced absorption

• Liposomal formats under development

This next-generation nutrient represents a breakthrough in mitochondrial medicine, with clinical potential extending from neurodegenerative diseases to sports nutrition.