Baikal Skullcap Extract (Scutellaria baicalensis): A Potent Phytotherapeutic Agent

What is Baikal Skullcap Extract Powder?

Scutellaria baicalensis, also known as Chinese skullcap, is a perennial flowering plant highly prized for its reputed medicinal properties. The low-growing plant bears flowers that vary from blue to purple. Long a mainstay of traditional Chinese medicine, skullcap roots are ground into powder that is used to treat a variety of ailments, including allergies, headaches, infections and inflammation. Research studies have confirmed some of the traditional claims for this herbal remedy and have also revealed other health benefits.

Baicalin and Baicalein are herbal supplements that have anti-neuroinflammatory, anticancer and anti-anxiety effects.

Baicalein is a flavone, a type of polyphenolic flavonoid, that is extracted from the roots of Scutellaria baicalensis and Scutellaria lateriflora that have a wide variety of health benefits.

Baicalin is a flavone glycoside, the glucuronide of baicalein, which is obtained through the binding of glucuronic acid to baicalein. It is primarily used in Asian countries as an herbal supplement.

Pharmacological Properties

• Flavonoid-Rich Composition: Contains >85% bioactive flavonoids, primarily baicalin (40-60%), baicalein (10-20%), and wogonoside (5-10%)

• Multitarget Bioactivity:

• Neuroprotective: Modulates GABA(A) receptors and exhibits anxiolytic effects

• Anti-Inflammatory: Inhibits COX-2, LOX, and NF-κB pathways

• Antiviral: Demonstrates activity against influenza, SARS-CoV-2, and HSV

• Hepatoprotective: Upregulates Nrf2-mediated antioxidant defenses

Mechanistic Insights

• Baicalein: Potent free radical scavenger (ORAC value >30,000 μmol TE/g)

• Wogonin: Selective PDE4 inhibitor with immunomodulatory effects

• Synergistic Action: Flavonoid complex enhances bioavailability and therapeutic breadth

Clinical Applications

• Neurological Formulations: Cognitive support, anxiety management

• Hepatoprotective Therapies: Liver detoxification adjunct

• Oncological Adjuvants: Chemopreventive properties in phase II trials

• Dermatological Preparations: Atopic dermatitis and psoriasis management

Quality Specifications

• Standardization: Minimum 45% total flavonoids (HPLC)

• Solubility: Water-soluble derivatives available (baicalin-β-cyclodextrin complexes)

• Stability: Protected from light and oxidation (recommended nitrogen flushing)

Dosage & Safety

• Therapeutic Range: 100-500 mg/day (standardized extract)

• Drug Interactions: Potential CYP3A4/P-gp modulation

• Regulatory Status: GRAS-affirmed, compliant with USP/EP monographs

This scientifically validated adaptogen represents a paradigm shift in multifunctional botanical therapeutics, combining traditional wisdom with evidence-based applications.

Functions of Baikal Skullcap Extract Baicalin

1. Lowers Anxiety

2. Neuroprotective

3. Fight Cancer

4. Protects the Liver

5. Improves Lung Function

6. Help Your Eyes

7. Improves Fertility