Luteolin is a kind of natural flavonoids, mostly in the form of glycosides in a variety of plants. These plants have a higher content of whole-leaf green orchid, pepper, wild chrysanthemum, honeysuckle, and perilla. It has antitussive and expectorant effects. It has a variety of pharmacological activities, such as anti-inflammatory, anti-allergic, uric acid lowering, anti-bacterial, anti-viral, etc. It is mainly used clinically to relieve cough, expectorant, anti-inflammatory, lower uric acid, treat cardiovascular diseases, and treat "amyotrophic lateral sclerosis" ", SARS, hepatitis, etc.

Physical properties: yellow needle-like crystals, melting point 328-330°C. Slightly soluble in water, weakly acidic, soluble in alkaline solution, stable under normal conditions.

1. Anti-inflammatory

It is believed that the anti-inflammatory activity of luteolin is related to inhibiting the production of nitric oxide (NO) and other inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), and inhibiting protein complex The phosphorylation of amino acid is related to gene expression mediated by nuclear transcription factor KB (NF-KB).

2. Anti-allergy

Luteolin can inhibit immunoglobulin E (IgE)-mediated allergy transmitters produced by human mast cells, including histamine, leukotrienes, prostaglandin D2, and the release of monocyte-macrophage colony stimulating factor. The effect may be related to the inhibition of Ca2+ influx and protein kinase C (PKC) translocation activation.

3. Anti-inflammatory demyelinating diseases

Luteolin can protect oligodendrocytes from oxidative damage induced by hydrogen peroxide in a dose-dependent manner in vitro, strongly inhibit the phagocytosis of myelin by macrophages, significantly reduce the production of cellular reactive oxygen species, and reduce the expression of iNOS protein. At low doses, the level of NO produced by macrophages was significantly reduced.

4. Anti-fibrosis

98% Luteolin Powder can reduce the degree of liver fibrosis, reduce the content of hydroxyproline (HYP), malondialdehyde (MDA) and the expression of type I procollagen mRNA in liver tissues, and can inhibit hepatic stellate cells (HSC) in vitro Proliferation and collagen synthesis. It can also improve the histopathological changes of pulmonary fibrosis caused by bleomycin, reduce lung mass index, significantly reduce the increase of MDA and HYP, and inhibit the expression of transforming growth factor-β1 (TGF-β1) mRNA in lung tissue , In vitro can inhibit the proliferation of human embryonic lung fibroblasts and promote their apoptosis.